Cognitive Functions Affected by Scopolamine in Alzheimer’s Disease and Normal Aging
نویسندگان
چکیده
Huff, F.J., S.F. Mickel, S. Corkin, and J.H. Growdon: Cognitive functions affected by scopolamine in Alzheimer’s disease and normal aging. Drug Dev. Res. 12:271-278, 1988. We gave scopolamine to patients with Alzheimer’s disease (AD) and age-matched control subjects in order to identify which cognitive functions are affected by blocking muscarinic receptors for acetylcholine (ACh). Both subject groups showed dose-related impairments in verbal learning, and patients with AD exhibited enhanced vulnerability to effects of scopolamine on attentional vigilance. In the same dose range, scopolamine did not alter retrieval from long-term lexical-semantic memory or performance on a test of visual discrimination, suggesting that cholinergic neurotransmission is not critical for these cognitive functions. The importance of cholinergic transmission in learning and attention is confirmed by this study, and the results indicate that both these abilities should be measured in investigations of potential cholinergic treatments for AD.
منابع مشابه
Improvement of cognitive deficit of curcumin on scopolamine-induced Alzheimer’s disease models
Background: It has been suggested that curcumin may be useful in diseases with cognitive dysfunction because it slows the progression and leads to the improvement of cognitive functions. In this study, the protective effects of curcumin on scopolamine-induced rat models of cognitive impairment were evaluated. Methods: 21 male Wistar Albino rats, 1 year old, 200±25 grams, were included in the s...
متن کاملEffects of harmalol on scopolamine-induced memory disorders, anxiety and depression like behaviors in male mice: A behavioral and molecular study
Introduction: Harmalol is a dihydrocarboline compound found naturally in several alcoholic beverages and medicinal plants. This study was designed to investigate the effect of harmalol on memory function and its possible mechanisms in a scopolamine-induced memory disorder model. Materials and Methods: Thirty five male mice were randomly divided into five (n=7) group: Control group )normal sali...
متن کاملVitamin E therapy prevents the accumulation of congophilic amyloid plaques and neurofibrillary tangles in the hippocampus in a rat model of Alzheimer’s disease
Objective(s): Vitamin E may have beneficial effects on oxidative stress and Aβ-associated reactive oxygen species production in Alzheimer’s disease. But, the exact role of vitamin E as a treatment for Alzheimer’s disease pathogenesis still needs to be studied. Hence, we examined the therapeutic effects of vitamin E on the density of congophilic amyloid plaques and neur...
متن کاملKUOPION YLIOPISTO UNIVERSITY OF KUOPIO Neurologian klinikan julkaisusarja, No 51, 2000 Series of Reports, Department of Neurology JUKKA PUOLIVÄLI AN EXPERIMENTAL STUDY ON THE CHOLINERGIC MODULATION OF CORTICAL AROUSAL AND COGNITIVE FUNCTIONS
The brain cholinergic system is involved in a number of behaviors including arousal and cognitive processes. In Alzheimer’s disease (AD) patients, the function of the cholinergic system is severely compromised. AD patients with apolipoprotein E (apoE) ε4 allele(s) suffer more pronounced cholinergic deficits which are associated with severe cognitive impairments, pronounced cortical electroencep...
متن کاملEffects of scopolamine on matching to sample paradigm and related tests in human subjects.
This was a double-blind placebo-controlled study with a cross-over design to examine the effects of scopolamine on cognitive functions in young healthy subjects. Scopolamine hydrobromide was administered subcutaneously to 12 subjects (mean +/- SD age 23.8 +/- 2.2 years) at doses of 0.3 and 0.6 mg in comparison with two placebo conditions. Scopolamine at both doses produced marked sedation as ra...
متن کامل